Pacy winger Issaka made history for Argyle on 31 August, 2021 as he made his first-team debut for the Greens at just 15 years and 34 days old coming on in the EFL Trophy tie against Newport County. This made him the youngest player ever to represent Argyle's first team. 

Issaka scored his first goal for Argyle in October 2024, in a 3-3 comeback draw against Preston North End at Home Park.